Role of catecholamine hormone in heroin addicts

Objective:To investigate the effects of catecholamine hormone on the blood and bra in of hero in addicts.Methods:Rats were divided into three groups and treated with the glucose(control group),the heroin(im)(hero in group),and the combination of the intramuscular injection of reserpine and heroin(reserpine group).Changes in the levels of the dopamine(DA),cAMP,and cGMP were detected by the radioimmunoassay(RIA)method in the blood and bra in tissue.Results:No significant with drawal symptoms were observed in the reserpine group.Compared with the control and hero in groups,the blood cAMP levels were increased by 35.36% and 15.53% in the reserpine group,respectively;the cAMP levels in the midbra in ventral tegmental area(VTA),prefrontal cortex(PFC),and hippocampus(Hipp) were increased by 24.08% 8.53%,15.66% 8.13%,and 21.95% 8.40%,respectively.While compared to the control and hero in groups,the DA levels of the PFC,Hipp,striatum,and nucleus accumbens(NAc) were significantly reduced in the reserpine group,decreasing by 74.09% 82.86%,81.06% 82.23%,91.62% 86.55% and 84.35% 90.63%,respectively.The concentrations of cGMP of the bra in tissues in the reserpine group were lower than those in the control group.In addition,the neural electrophysiological testing showed that the electroencephalogram(EEG),electrocardiogram(ECG),and muscle spindle discharge diagram of rats in both the reserpine and hero in groups were apparently changed.Conclusion:Catecholamine hormone plays an important role in hero in addiction.