Binding Properties of the Conjugates of Oligo(2′‐O‐Methylribonucleotides) with Minor Groove Binders Targeted to Double Stranded DNA
2004
Design, synthesis, physico‐chemical and in vitro biological studies of new pyrimidine oligo(2′‐O‐methylribonucleotide) conjugates with oligocarboxamide minor groove binders (MGB) and benzoindoloquinoline intercalator (BIQ) are described. These conjugates formed stable triple helices with the target double‐stranded DNA and inhibited its in vitro transcription upon binding.
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