TMS×OTf‐Catalyzed α‐Bromination of Carbonyl Compounds by N‐Bromosuccinimide.

Abstract Various carbonyl compounds undergo α-bromination reaction under a mild and practical condition utilizing N -bromosuccinimide (NBS), catalyzed by trimethylsilyl trifluoromethanesulfonate (TMS·OTf). This method is also effective for the side-chain bromination of heteroaromatic carbonyl compounds without the ring brominations.