Adenosine Inhibition of Human Platelet Aggregation by ADP

WE have shown that in human platelet-rich plasma, inosine is a concentration-dependent inhibitor of adenosine incorporation into platelets1,2 and at high concentrations inosine inhibits adenosine decomposition3. This prompted us to investigate the effect of inosine and other adenosine decomposition products on aggregation of human platelets in vivo by ADP.