Effects of positive airway pressure on pulmonary function parameters

Background: Few studies have assessed the immediate effects of positive airway pressure, such as the Expiratory Positive Airway Pressure (EPAP) and Flutter devices, on pulmonary function. Objective: The objective of this study was to assess the immediate changes in pulmonary function after using the EPAP and Flutter devices in patients with cystic fibrosis.  Methods: Fourteen patients aged 18±3 years with varied mixed severity of pulmonary disease were enrolled. EPAP (15cmH 2 O) and Flutter were used for 15 minutes, randomly, within a week interval. The helium dilution test was used to measure the functional residual capacity, total lung capacity and residual volume. Statistical analysis was performed using two-way ANOVA, and p 0.05 for all comparisons). Conclusions: Therefore, in the assessed patients, the use of Flutter and EPAP did not promote significant short-term changes in pulmonary function.