Improvement of learning and memory functions by GABAB receptor antagonists in mice

In one trial passive avoidance response in mice,the effects of γ-aminobutyric acid(GABA)B receptor agonist baclofen and antagonist CGP35348 and CGP36742 on acquisition,consolidation and retrieval of memory were observed.The tesults showed that the antagonists couldsignificantly promote the acquisition impairment induced by baclofen, the consolidation impainnentinduced by baclofen and NaNO2,and the retrieval impairment induced by baclofen and 30 % alcohol.These results suggest that the GABA Breceptor antagonists may become a novel type of drug for thetreatment of Alzheimer'sdisease.