Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor

Essa Hu,Peter C. Chua,Lida R. Tehrani,Johnny Y. Nagasawa,Anthony B. Pinkerton,Blake Rowe,Jean Michel Vernier,John H. Hutchinson,Nicholas Cosford

Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor

2004

Essa Hu
Peter C. Chua
Lida R. Tehrani
Johnny Y. Nagasawa
Anthony B. Pinkerton
Blake Rowe
Jean Michel Vernier
John H. Hutchinson
Nicholas Cosford

Abstract Pyrimidine methyl anilines as potent and selective mGlu2 potentiators are described. Findings from the structure–activity-relationship investigations are discussed.

Keywords:

Pyrimidine
Metabotropic receptor
Potentiator
Organic chemistry
Aromatic amine
Biochemistry
Glutamate receptor
Structure–activity relationship
Metabotropic glutamate receptor
Chemistry
Receptor
Stereochemistry
Chemical synthesis

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