Microvesicles-mediated Cell Communication in Pulmonary Arterial Hypertension.

Background Pulmonary arterial hypertension is one of the chronic diseases that affect the human health. Microvesicles participate in the communication between cells by fusing with the recipient cells to transfer the bioactive molecules, such as lipids, proteins, RNA, etc., to the target cells. Microvesicles are involved in various biological processes, and have the functions of regulating immunity, promoting angiogenesis and so on. Microvesicles derived from various cells may become diagnostic biomarkers or therapeutic targets to the diseases. Therefore, exploring the role of microvesicles-mediated cell communication has become a potential therapeutic target to pulmonary arterial hypertension. Objective It is to clarify the classification, features and mechanism of microvesicles in cell communication, and to discuss the potential important roles of microvesicles-mediated cell communication in pulmonary arterial hypertension. Results Inflammation is an important the pathogenesis of pulmonary arterial hypertension. Many studies have shown that microvesicles from different cells can participate in the pathological process of PAH by transferring the inflammatory factors contained in them. Conclusion Microvesicles-mediated cell communication may become the therapeutic target to pulmonary arterial hypertension.