Analysis of the Expression Toll-Like Receptor 4 (TLR4) in Chronic Suppurative Otitis Media with and without Cholesteatoma

In recent years, the increasing incidence of chronic suppurative otitis media (CSOM) diseases worldwide is often associated with the role of TLR4 as a component of innate immunity. This study aimed to analyze the TLR4 levels in patients with chronic suppurative otitis media with and without cholesteatoma. This study was conducted using the cross-sectional technique on 30 patients divided into two groups. The first group is CSOM with cholesteatoma that consisted of 10 patients and the second group is CSOM without cholesteatoma that consisted of 20 patients. Each sample was examined for TLR4 levels and bacterial identification cultures in secretions and several samples were also examined for TLR4 levels in the middle ear mucosa. TLR4 levels were examined by the ELISA method.