Relationship between serumadiponectin and left ventricular geometry in patients with essential hypertension

：Objective To investigatethe relationship between serum adiponectin ( APN ) level and left ventricular geometry inpatients with essential hypertension. Methods Echocardiography was performed on 133patients with essential hypertension. According to left ventricular mass index ( LVMI) andrelative wall thickness ( RWT ), patients were divided into normal geometry group ( n = 37), concentric remodeling group ( n=32 ), concentric hypertrophy group ( n = 34 )andeccentric hypertrophy group ( n = 30). 30 healthy subjects were used as control. Serum APNlevels were measured by enzyme-linked immunosorbent assay. Results Serum APN levels didnot differ significantly among the control group, the normal geometry group, and theconcentric remodeling group ( P>0.05 ). As compared with those in the control group,serum APN levels were markedly lower in the concentric hypertrophy group and the eccentrichypertrophy group ( P< 0.01 ), especially in the latter group ( P< 0.01 ). APNlevels were negatively related with LVMI ( P < 0.05 ) in those with ventricularhypertrophy. Conclusions Serum APN levels can still reflect the degree of left ventricularhypertrophy in hypertensive patients receiving standard therapies.