Tu2032 Effect of -(1,3-1,6)-D-glucan Against Irritable Bowel Syndrome-Related Colonic Hypersensitivity

and hyperplastic polyps. Reviews of each studywere conducted and references were reviewed. The most adjusted risk estimates were extracted by two independent authors and summarized using random effects meta-analysis with Comprehensive meta-analysis software version 2.0. Results 6 studies were eligible for analysis. They combined a randomized controlled trial, case-control and cohort studies. Most studies showed a reduction in the incidence of colorectal adenoma. The overall summary risk estimate by a random effects meta-analysis for Vitamin D supplementation and adenoma formation was RR= 0.821, 95% CI 0.675 to 0.997 (P < 0.001). There was evidence of publication bias among the different studies included. The heterogeneity was relatively low as shown by an I2 value of 38.75. Conclusion Our metaanalysis results suggest that when vitamin D is taken as a supplement it acts as a protective agent against colorectal adenoma formation.