The Total Synthesis of Heraclemycin B through β‐Ketosulfoxide and Aldehyde Annulation

Herein we describe a total synthesis of the natural product heraclemycin B. This synthetic approach follows a Diels–Alder strategy to form the anthracenone core followed by a β-ketosulfoxide and aldehyde annulation to form the 4-pyranone D ring. The spectral data for the synthesized product matches that reported in the isolation studies.