Protein structural similarity database: the architecture and implementation

The work described in this thesis builds upon ProBiS algorithm for comparison of protein structures. Such comparisons can be very time consuming. The main goal of our project was their pre computation and development of the ProBiS database. Thesis begins with a description of ProBiS algorithm and a web page, through which it operates. Our main contribution is construction of appropriate architecture of the system and its implementation using distributed computation, and construction of a database and its further optimization through denormalization. We have also implemented the user interface for searching the database. Our newly developed ProBiS database is a novel resource for protein structural comparisons and greatly improves the user experience of ProBiS web server.