АНТИТЕЛА К БЕНЗО[А]ПИРЕНУ И ЭСТРАДИОЛУ И ПОЛИМОРФИЗМ ГЕНОВ ЦИТОКИНОВ ПРИ РАКЕ ЛЁГКОГО У МУЖЧИН

The associations of antibodies to benzo[a]pyrene and estradiol (IgG-Bp, IgG-Es) with IL1B (rs1143634, rs16944), IL1RN (VNTR, intron 2), IL4 (VNTR, intron3), IL6 (rs1800795), IL10 (rs1800896), TNFA (rs1800629, rs361525) gene polymorphisms in 228 smoking healthy men (NM) and 657 lung cancer patients (LCP)were studied. There was revealed association of gene polymorphism only of TNFA (rs1800629) with LC, but not others cytokines. LC risk in GG carriers was high (OR = 1,1–2,3; p = 0,007) and in GA carriers was low (OR = 0,4–0,9; p = 0,01). LC risk was low (OR = 0,3–0,7; p = 0,0002) when both IgG-Bp and IgG-Es were absent. LC risk was high (OR = 1,8–4,4; p = 0,0001) when levels both IgG-Bp and IgG-Es were increased. IgG-Bp and IgG-Es formation was associated with TNFA (rs361525) gene polymorphism in HM (p = 0,007), and with IL1RNVNTR genepolymorphism (p = 0,003) and IL1B (rs16944) (p = 0,007) in LCP. There have first reported a relationship between cytokines gene polymorphisms and specific immune responses on chemical carcinogens and endogenous steroids in healthy donors and lung cancer patients. Immunoassays of IgG antibodies to Bp and Es combined with molecular-genetic studies of TNFA (rs361525), IL1RNVNTR and IL1B (rs16944) are recommended for the lung cancer risk assessment.