Forced Expiratory Volume in 1 Second Is Not Affected by Exposure to Diesel Exhaust and Cycling Exercise in Individuals with Exercise-Induced Bronchoconstriction

PURPOSE: To assess the effect of diesel exhaust (DE) exposure before and during cycling exercise in individuals with exercise-induced bronchoconstriction (EIB) on lung function following the inhalation of a bronchodilating agent (salbutamol, SAL).METHODS: Seventeen 22-34 year-olds (9 females) with an EIB diagnosis were included in this double-blind randomized crossover study. In four exposure visits, participants performed a 30-minute cycling bout while breathing either DE or filtered air (FA) after the inhalation of either 400μg of SAL or placebo (PLA). After the inhalation of SAL or PLA, participants sat in the exposure chamber for 60 minutes. Following this rest period, participants cycled for 30 minutes at 50% of peak work rate achieved on their screening visit. During both the rest and cycling bouts, participants breathed either DE (PM2.5 = 300μg/m3) or FA. Forced expiratory volume in 1 second (FEV1) was assessed at baseline, after the 60-minute resting period, immediately upon completi...