Chronic Allopregnanolone Treatment Accelerates Alzheimer's Disease Development in AβPPSwePSEN1ΔE9 Mice

Sara K. Bengtsson,Maja Johansson,Torbjörn Bäckström,Ming-De Wang

Chronic Allopregnanolone Treatment Accelerates Alzheimer's Disease Development in AβPPSwePSEN1ΔE9 Mice

2012

Sara K. Bengtsson
Maja Johansson
Torbjörn Bäckström
Ming-De Wang

The endogenous neurosteroid allopregnanolone alters neuronal excitability via modulation of the GABA(A) receptor and causes decreased neurotransmission. In Alzheimer's disease (AD), neurotransmissi ...

Keywords:

Psychology
Endocrinology
Neuroactive steroid
Internal medicine
Endogeny
Allopregnanolone
Disease
Neurotransmission
Anesthesia
Receptor
PSEN1
Diabetes mellitus

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