Acetaminophen and Sulphatiazole Release from Biodegradable Copolymers

This study is focused on release of acetaminophen and sulphatiazole from biodegradable copolymers. Acetaminophen is one of the most widely used analgesic and antipyretic. Acetaminophen it was chosen as a model drug for its good water solubility. The representative of sulfa antibiotics – sulphatiazole was chosen as another model drug. Sulphatiazole is used to treat burns and leg ulcers and it is practically insoluble in water [1]. Polymers allow creating the carrier for low-molecular medicament due to its structure and high molecular weight. Drug loading to polymer structure will be circulating in organism longer. The medicament may circulate days, weeks to months depending on the polymer structure. It is possible to achieve a prolonged effect or controlled drug release [2]. Acetaminophen and sulphatiazole were released from copolymers based on poly(lactic-co-glycolic) acid and poly(ethylene glycol) PLGA-PEG-PLGA. This group of copolymers is considered the stimuli-responsive polymers. Copolymers based on PLGA-PEG-PLGA are sorted into groups of temperature-sensitive polymers. The sol copolymer becomes hydrogel copolymer with increasing temperature and vice versa [3]. Release of acetaminophen and sulphatiazole occurred at 37 °C in MilliQ-water and phosphate buffer solution pH value 7.4. High performance liquid chromatography coupled with mass spectrometry used for quantitative determination of acetaminophen and sulphatiazole. Acknowledgment This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic, specific research, No. FCH-S-15_2869. [1] F. Hampl, S. Radl, J. Palecek, // Farmakochemie, 2. rozsiřene vyd. Praha: VSCHT Praha, 2007, p. 450, ISBN 978-80-7080-639-5. [2] NGUYEN, M. K., LEE, D. S.. Injectable Biodegradable Hydrogels. Macromolecular Bioscience. 2010, vol. 10, pp. 563-579. DOI: 10.1002/mabi.200900402. [3] B. Jeong, A. Gutowska, // Lessons from Nature: Stimuli-Responsive Polymers and their Biomedical Applications. Trends in Biotechnology, vol. 20, 2002, pp. 305-311, ISSN 0167-7799.