MUTAÇÕES NO GENE RRNA 23S ASSOCIADAS COM A RESISTÊNCIA À LINEZOLIDA EM STAPHYLOCOCCUS SPP i MUTATIONS IN 23S RRNA GENE ASSOCIATED WITH RESISTANCE TO LINEZOLID IN STAPHYLOCOCCUS SPP LAS MUTACIONES EN EL GEN 23S RRNA ASOCIADAS CON RESISTENCIA A LINEZOLID EN STAPHYLOCOCCUS SPP

Linezolid, the first agent of the oxazolidinone class to be introduced clinically, is potentially active against important bacterial pathogens, including multi-resistant Staphylococcus spp. This new oxazolidinone inhibits protein biosynthesis by binding to the peptidyl transferase center (PTC) of the 50S subunit of the bacterial ribosome. Although linezolid resistance can be mediated by the cfr-encoded product or by mutations in the ribosomal proteins