Clinical pharmacokinetic-pharmacodynamic (PK/PD) modeling study of the novel dual PI3K/mTOR inhibitor BEZ235.

3056 Background: BEZ235 is a novel pan-class I PI3K/mTOR inhibitor with proven apoptotic effect (Brachman et al 2009), antiangiogenic effect (Schnell et al 2009) and clinical activity especially in...