Altered relation of resting-state alpha rhythm with blood oxygen level dependent signal in healthy aging: evidence by EEG-fMRI fusion analysis

Abstract Objective The goal of this study is to explore the changes of spatial correlates of alpha rhythm in the aged adults. Methods Electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) data were simultaneously recorded from 27 young and 19 elderly adults at resting state with their eyes closed. Alpha rhythm power fluctuation was extracted from EEG signal of parietal-occipital region and was fused with fMRI data by correlating alpha rhythm with blood oxygen level dependent (BOLD) signal using general linear models. Results For both young adults and the elderly, the regions correlated with alpha rhythm power were widely distributed in cortical and subcortical regions. However, compared to young adults, correlations between alpha rhythm and the activity of thalamus and frontal regions were significantly reduced in the elderly. In addition, an increased correlation with alpha rhythm was found in frontal, insula and cingulate gyrus regions in the elderly. Conclusions Changes in the roles of the above brain regions may be present in the generation or modulation of alpha rhythm due to age advancing. Significance This study provides novel insight into the alteration of the spatial correlates of alpha rhythm in the elderly by using simultaneous EEG-fMRI data fusion analysis.