Prism adaptation improves neglect-related motor perseveration (P5.175)

Prism adaptation may improve motor-intentional deficits in a patient with chronic post-stroke left spatial neglect. While performing four cancellation tasks, he displayed left-sided omissions and three types of motor perseverative errors: additional marks (AM), scribbles, and flying marks (FM). After two weeks of home-based Prism Adaptation therapy, our patient cancelled an average of 19.6[percnt] more targets on all four cancellation tasks and improved significantly on figure copying/drawing. Consistent with Gandola et al 2013 who showed that only AM and FM errors are related to neglect severity, we predicted that PAT would improve these perseverative errors, but have no effect on scribbles. A t-test evaluating percent changes in AM/FM Density (mean = -0.633, std. dev. = 0.243) and in Scribble Density (mean = -0.030, std. dev. = 0.220) showed a trend (one-tailed t(3)=-1.86, p=0.08), but did not reach significance. PAT did decrease the density of AM/FM errors by over 63.3[percnt]. AM and FM errors may be related to motor-intentional Aiming mechanisms, thereby making them more susceptible to prism therapy. Further research is needed to examine whether prism adaptation may be effective for all individuals with AM or FM motor perseverative errors, even if they do not meet the clinical criteria for spatial neglect. Disclosure: Dr. Chaudhari has nothing to disclose. Dr. Barrett has received personal compensation for activities with Medscape/emedicine. Dr. Barrett9s institution has received research support from NIH, NIDRR, the Healthcare Foundation of NJ, the Mabel H. Flory Trust, the Wallerstein Foundation for Geria