Unique expression profiles of mucin proteins in interstitial pneumonia-associated lung adenocarcinomas.
2019
In order to clarify idiopathic interstitial
pneumonia (IIP)-associated lung adenocarcinoma
(LADC), we herein focused on the expression profiles of
mucin proteins, the most common cellular differentiation
markers. The expression of the mucin (MUC) 1, MUC2,
MUC3B, MUC4, MUC5AC, MUC5B, MUC6, MUC7,
MUC9, and MUC21 proteins was examined
immunohistochemically and their levels were semiquantified in 80 IIP-associated LADCs and 106 non-IIP
LADCs. LADCs were divided into low and high
expressers based on thresholds obtained from the
receiver operating characteristic (ROC) curves of each
mucin protein. Low expressers of MUC1, MUC7, and
MUC21 and high expressers of MUC4, MUC5AC,
MUC5B, and MUC9 were dominant in the IIP group.
Multivariate analyses confirmed that the correlations
between mucin expression profiles and IIP-associated
LADCs were independent of putative confounding
factors, such as smoking, gender, histological types, and
cytological types. Thus, the expression profiles of these
mucin proteins significantly differed between the IIP and
non-IIP groups. IIP-associated LADCs appear to have
unique cellular differentiation features and they may
develop through a distinct histogenetic pathway. This is
the first study to demonstrate that IIP-associated LADCs
have unique mucin expression profiles.
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