Fabrication of Liquid Molds using Drop-on-demand Printing Technologyfor Bio-Pdms Mirofluidic Devices

A simple and easy method is demonstrated for the fabrication of liquid molds which was used for the fabricaion of bio-polydimethylsiloxan (Bio-PDMS) mirofluidic devices based on a novel drop-on-demand (DOD) printing technology. The liquid molds were DOD printed well on the hydrophilic glass substrate which was treated with a TiO2 nanoparticles (TiO2NPs) solution at the overlap of 30%. Then the PDMS concave molds were fabricated well by being replicated from the liquid molds and were bonded with another PDMS substrate to form a Bio-PMDS mirofluidic device. The micro-channel which the width and the height were about 100 μm and 8 μm was fabricated and the surface roughness of the micro-channel with the 100×320 μm2 area was about 179 nm measured by a white light interferometer. The experimental results showed that the width of micro-channel in the Bio-PDMS microfluidic device was small and the surface of the micro-channel was smooth.