Prognostic nomogram for overall survival in early-stage extranodal natural killer/T cell lymphoma treated with high-dose radiotherapy
2019
Abstract The aim of this study is to develop a prognostic nomogram for early stage extranodal NK/T-cell lymphoma, nasal-type (ENKL) treated with high-dose radiotherapy (RT). A total of 81 patients at two cancer centers with stage I to IIE ENKL who received chemotherapy (CT) and high-dose RT were retrospectively analyzed. The 5-year OS rate and PFS were 64.7% and 57.5% respectively for the entire group. The development of the nomogram was based on the Cox proportional hazards model. We have implemented the concordance index (C-index) and performed a calibration curve to determine its predictive and discriminatory capacity and compared our study with the International Prognostic Index (IPI) and the Korean Prognostic Index (KPI). The nomogram included four important variables based on a multivariate analysis: lactate dehydrogenase, primary tumor invasion, tumor response, and CT regimen. The C-index of the nomogram for the OS prediction was 0.87, and it was superior to the predictive power of the IPI and KPI. The calibration curve showed that the nomogram was able to predict the 5-year OS accurately. The proposed nomogram is able to provide an individualized risk estimate of the OS for early stage ENKL treated with CT and high dose RT.
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