The effects of cutting balloon angioplasty on endothelium function in patients with unstable angina pectoris

Objective To investigate the effects of cutting balloon angioplasty(CBA) on serum secretion of endothelium function in patients with unstable angina pectoris Methods A total of 65 patients with unstable angina pectoris were randomly divided into CBA group and balloon angioplasty (BA) group Stents were planted in all patients after balloon angioplasty Coronary sinus blood was collected before angioplasty, immediate after angioplasty as well as 2h and 6h after angioplasty to measure the content of serum nitric oxide (NO), plasma endothelin (ET 1) and serum vigor of nitric oxide synthase (NOS) The serum level of NO and vigor of NOS were measured by chemical analysis The plasma level of ET 1 were measured by radioimmunoassay Results There was no significant difference of the characteristics of the target lesions between the two groups The maximum balloon filling pressure and the implantation pressure of stent in CBA group was significantly lower than that in BA group ( P 0 05) The serum level of NO and vigor of NOS were significantly higher in CBA group than those in BA group immediate and 2h after angioplasty ( P 0 05) The plasma level of ET 1 was significantly higher in BA group than that in CBA group immediate and 2h after angioplasty ( P 0 05) Conclusions The results suggest that CBA can significantly reduce the production of ET 1 and has lower influence on serum level of NO and vigor of NOS than that of BA This may suggest that CBA plus stent implantation produce less vessel wall injury and, consequently, better reserve secrete function of endothelium, which may account for the lower rate of restenosis and cardiovascular events of CBA