Cerebrospinal fluid amounts of HLA-G in dimeric form are strongly associated to patients with MRI inactive multiple sclerosis

Abstract The relevance of human leukocyte antigen (HLA)-G in dimeric form in multiple sclerosis (MS) is still unknown. To investigate the contribution of cerebrospinal fluid (CSF) HLA-G dimers in MS pathogenesis. CSF amounts of 78-kDa HLA-G dimers were measured by western blot analysis in 80 MS relapsing-remitting MS (RRMS) patients and in 81 inflammatory and 70 non-inflammatory controls. CSF amounts of 78 kDa HLA-G dimers were more frequent in RRMS than in inflammatory (p