Association of malignant neoplasms of other organs in patients with primary hyperparathyroidism

: There are several reports of an increased occurrence of nonparathyroid cancer in patients with primary hyperparathyroidism. Whether there is a cause and effect relationship has not been established. Especially, the coexistence of the parathyroid and thyroid tumors appears significantly high. Recently PRAD 1 was determined the one of the oncogenes of parathyroid adenoma. Interest in PRAD 1's role with respect to oncogenesis has been intensified by its incrimination in other, nonparathyroid, human tumors. If properly conducted surveillance programs do indicate a higher likelihood of cancer in patients with primary hyperparathyroidism, the current philosophy that the patient with mild and asymptomatic hyperparathyroidism does not need the surgery must be reevaluated.