Shear stress and platelet-induced tensile forces regulate ADAMTS13-localization within the platelet thrombus

Background The multimeric glycoprotein von Willebrand factor (VWF) mediates platelet adhesion and aggregation at the site of vessel injury. The adhesive activity of VWF is influenced by its multimer length which is regulated by the metalloprotease ADAMTS13. The ability of ADAMTS13 to regulate platelet thrombus growth in a shear‐dependent manner has been described, however, the mechanistic basis of this action has not been well characterized.