Клинико-психопатологические особенности шизофрении с манифестацией в юношеском возрасте на этапе отдаленного катамнеза

Background: analysis of the long-term course and outcomes of youth schizophrenia is still an actual problem. Objective: determination of clinical-psychopathological features of the condition of patients with youth schizophrenia in the long-term follow-up study. Patients and methods: presents the results of the long-term follow-up study of 320 patients with youth schizophrenia first applied in the PND N1 in Moscow from 1990 to 1994. Follow-up was 20-25 years. Clinical and psychopathological, follow-up, epidemiological and statistical methods, and also a psychometric method (PSP) were applied. Results: three types of follow-up outcomes were found. The first type with a predominance of personality dynamics (49,4%) included three variants: 1) predominance of the «primary defect» in the form of exaggeration of personality traits (18,1%); 2) predominance of the «primary defect» in the form of distortion or transposition of personality traits (10,0%); 3) the amalgamation of productive disorders in the structure of the «primary defect» (21,3%). The second type (24,7%) with actual negative disorders included states with the dominance of deficiency symptoms (14,1%) and states with the dominance of pseudo-organic symptoms (10,6%). The third type (25,9%) with relevant positive and negative disorders included cases with the isolated existence of productive and negative disorders («fragments psychotic») (10,0%) and states with active psychotics (15,9%). Conclusions: the found types of long-term follow-upoutcomes were associated with social and labor functioning of patients.