Long-term follow-up of patients treated with neoadjuvant chemotherapy and radiotherapy for large extremity soft tissue sarcomas.

10022 Background: Patients with large, high-grade, extremity soft tissue sarcomas (STS) are at significant risk for distant recurrence and death. A regimen of preoperative chemotherapy consisting of mesna, adriamycin, ifosfamide, and dacarbazine (MAID), interdigitated with radiotherapy (XRT) and followed by resection and postoperative chemotherapy with or without XRT, has demonstrated high rates of local and distant control. We report the long-term follow-up data on 48 patients treated with this regimen compared to an historical matched control patient population. This is the pilot study on which the RTOG based a multi-institutional study. Methods: Adult patients with high-grade extremity STS ≥ 8 cmwere treated with three cycles of preoperative chemotherapy combined with 44 Gray of XRT followed by surgery. Three cycles of postoperative MAID were planned. For patients with positive surgical margins, 16 Gray of XRT was delivered postoperatively. Results: Patients received the MAID/XRT regimen from 1989 thro...