The effect of N-(α-Methylbenzyl) linoleamide on experimental atherosclerosis in rabbits

Summary The effect of N -( α -methylbenzyl) linoleamide (MBLA) on experimental atherosclerosis in rabbits was investigated at various dose levels in comparison with those of N -cyclohexyl linoleamide (CHLA) and β -sitosterol. (1)MBLA and CHLA had marked lipid-lowering and anti-atherogenic effects, but MBLA was more effective than CHLA. (2)At the dose level of 800 mg/day, β-sitosterol lowered serum cholesterol, but less so than MBLA at 100 mg/day. (3)With daily administration of 400 mg of MBLA, elevation of serum cholesterol and development of aortic atherosclerosis were almost completely pre/ented in rabbits fed 1.6 g cholesterol daily. MBLA lowered serum cholesterol and exhibited an anti-atherogenic effect at the dose level of 25 mg/day.