Relationship between apolipoprotein E and low density lipoprotein particle size

Abstract The relationships between the particle size of low density lipoproteins (LDL) and various lipid parameters, including apolipoprotein (apo) E concentration and apo E phenotype, were analyzed in plasma samples obtained from 196 apparently healthy 35-year-old males. The LDL particle size was determined by gradient gel electrophoresis. Using stepwise multiple regression analysis it was found that LDL particle size correlated negatively to the plasma concentrations of triglyceride ( r = -0.497, P r = -0.415, P r = -0.395, P r = -0.235, P r = 0.297, P r = 0.145, P