Discovery of (2R)-N-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a potent and selective Janus Kinase 1 (JAK1) inhibitor

Qibin Su,Erica Banks,Geraldine Bebernitz,Kirsten Bell,Cassandra F. Borenstein,Huawei Chen,Claudio Chuaqui,Nanhua Deng,Andrew D. Ferguson,Sameer Kawatkar,Neil P. Grimster,Linette Ruston,Paul Lyne,Jon Read,Xian You Peng,Xiaohui Pei,Stephen Fawell,Zhanlei Tang,Scott Throner,Melissa Vasbinder,Haoyu Wang,Jon James Winter-Holt,Richard Woessner,Allan Wu,Wenzhan Yang,Michael Zinda,Jason G. Kettle

Discovery of (2R)-N-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a potent and selective Janus Kinase 1 (JAK1) inhibitor

2020

Abstract: JAK1 together with JAK2, JAK3, and TYK2 belong to the JAK (Janus kinase) family. They play critical roles in cytokine signaling. Constitutive activation of JAK/STAT pathways are associate...

Keywords:

Tyrosine kinase 2
stat
Janus kinase 1
JAK1 Inhibitor
Cytokine
Janus kinase
Chemistry
Biochemistry
Janus Kinase 1 Inhibitor

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