Delayed Effect of Hypotensive Drugs on Blood Pressure and Structure of the Myocardium in Hypertensive ISIAH Rats during Chronic Stress

Administration of antihypertensive drugs α 1 -adrenoceptor antagonist and Ca 2+ channel blocker during early ontogeny had various delayed effects on blood pressure in ISIAH rats with inherited stress-induced arterial hypertension under resting conditions and chronic stress. The drugs did not prevent the development of myocardial hypertrophy. Chronic stress had little effect on myocardial structure in adult animals.