High-concentration (20 mug/g) tacalcitol ointment therapy on refractory psoriasis vulgaris with low response to topical corticosteroids

Psoriasis is one of the chronic inflammatory skin diseases. It is characterized by reddening and thickening of the skin, and the psoriatic lesions are usually covered with silver scales. Although the pathophysiology of psoriasis is diverse, it is characterized by hyperproliferation of the epidermis associated with abnormal differentiation, and by migration of leukocytes from the dermis to the epidermis. Phototherapy and systemic therapy [...]