Process for preparing 4-[3-trifluoromethyl-5-(p-tolyl)-1H-pyrazolyl] benzene sulfonamide

The invention discloses a process for preparing type II epoxidation enzyme (COX-2) inhibiting agent 4-[3-trifluoromethyl-5-(p-tolyl)-1H-pyrazolyl] benzene sulfonamide (Celecoxib) by using 1-(p-cresyl)-4,4,4-trifluoro-1,3-butanedione and p-sulfamoyl phenylhydrazine hydrochlorate as raw material for reaction with homogeneous system comprising water and organic solvent including methanol or ethanol, ethylene glycol, propylene glycol, propanetriol, N, N-dimethyl formamide, N, N-dimethyl dimethylacetamide, 1-methyl-2-pyrrolidone, 1,3-dimethyl-3,4,5,6-tetrahydrochysene-2(1H)-pyrimidinone, 1,3-dimethyl-2-imidazolone, dimethyl sulfoxide, sulfolane, dioxane at room temperature.