Platelet-Rich plasma in androgenic alopecia: Myth or an effective tool

Introduction: Androgenic alopecia (AGA) is the most common form of alopecia, affecting up to 80% of men. Platelet-rich plasma (PRP) is an autologous preparation of plasma with concentrated platelets. PRP contains various growth factors and cytokines that enhance the body's inherent capacity to repair and regenerate. Materials and Methods: A study involves 20 patients suffering from AGA. The hair pull test was performed before the treatment session. The volume of 10 cc PRP was injected. The treatment was repeated every month for six times. The outcome was assessed after 6 months by clinical examination, global photos, hair pull test, and patient's overall satisfaction. Results: A significant improvement in hair loss was observed between the first and sixth injection of PRP. Hair count increased from the average number of 60 hair follicular units to 84 hair follicular units. The average mean gain in hair follicles is 24 units/cm2. After the 6th session, the pull test was negative in 17 patients. The average improvement before and after the procedure ranged from −2 to + 4 according to the 15-point Jaeschke scale. AGA is a disorder that is marked by the reduction in the diameter, length, and pigmentation of the hair. Growth factors in PRP are known to activate the proliferative phase and transdifferentiation of hair and stem cells and produce new follicular units. Conclusion: PRP injection is a simple, cost-effective, and feasible treatment option for AGA.