176 SUPPRESSION OF AUTOPHAGY ENHANCES PREFERENTIAL TOXICITY OF PACLITAXEL TO FOLLICULIN-DEFICIENT RENAL CANCER CELLS

Background Paclitaxel, a widely used chemotherapeutic drug, can induce apoptosis in variety of cancer cells. A previous study has shown preferential toxicity of paclitaxel to FLCN-deficient kidney cancer cell line, UOK257. In this report, we investigate the cellular and molecular mechanism of paclitaxel-induced autophagy and apoptosis in renal cancer cells with and without FLCN expression.