Transposition of exercise protocols: cardiovascular response to exercise in patients with transposition of the great arteries

The benefits of exercise at reducing cardiovascular and all-cause mortality have been well described, but certain cohorts of individuals exist in which the safety of exercise has not been studied and its benefits and harms are thus far unknown. During participation in sports or other forms of exercise, patients with transposition of the great arteries (TGA) with systemic right ventricles (SRVs) may have a higher risk of adverse events, including sudden cardiac death. There is little evidence regarding the exercise tolerance and safety in this cohort of patients and it is unknown if exercise will increase the stress on the SRV and result in diminished function.