EFFECT OF NITRIC OXIDE IN CHRONIC EXPERIMENTAL TOXOPLASMA GONDII INFECTION: HISTOPATHOLOGICAL AND HISTOCHEMICAL STUDY

Aim of the work: To evaluate the histopathological alterations and immuno-histochemical pattern in chronic Toxoplasma gondii infection, and to evaluate the role aminoguanidine in experimental toxoplasmosis. Subjects and methods: This study was carried out on 48 laboratory-bred male Swiss albino mice which were divided into 4 groups (non-infected control; infected control; infected and treated with spiramycin; infected and treated with aminoguanidine). The effect of the used drugs was assessed using parasitological, histopathological and immunohistochemical approaches. Results: There was highly significant (P