A NOVEL ZWITTERIONIC SILANE COUPLING AGENT FOR NONTHROMBOGENIC BIOMATERIALS

A novel silane coupling agent bearing sulfobetaine group, N,N-diethyl-N-(3-sulfopropyl)-aminopropyl-trimethoxysilane (DESATS), was first designed, synthesized and characterized. Its solution property was studied by means of dynamic light scattering. DESATS was successfully bonded onto the surface of the glass and proved by ESCA. Platelet adhesion assay in vitro indicated that the nonthrombogenicity of glass slide modified with DESATS is greatly improved.