The effect of Des-Arg9-bradykinin and bradykinin-potentiating peptide C on isolated rat hearts

Objectives: Des-Arg9-bradykinin and bradykinin-potentiating peptide C (BPPC) may contribute to the regulation of cardiovascular function. Therefore, we studied effects of these peptides on coronary perfusion pressure (CPP), heart rate, left ventricular developed pressure (LVDP) and maximum rate of increase of left ventricular pressure (+dP/dtmax). Methods: The isolated rat hearts were perfused with modified Krebs-Henseleit solution. Results: Infusion of 10, 100 and 1000 nM Des-Arg9-bradykinin decreased CPP (−13.6, −14.8 and −19.0%), LVDP (−16.5, −21.0 and −30.7%) and +dP/dtmax (−11.8, −17.8 and −23.7%), respectively (p < 0.001). Ten or 100 nM Des-Arg9-bradykinin did not alter heart rate, but 1000 nM increased it (+11.3%, p < 0.01). One, 10 and 100 nM BBPC reduced CPP (−16.3, −28.5 and −47.5%), LVDP (−12.6, −19.6 and −21.3%) and +dP/dtmax (−8.7, −18.6 and −20.3%), respectively (p < 0.001). BPPC increased heart rate at 1 nM (+9.6%, p < 0.05 ) and at 10 nM (+14.2%, p < 0.01), however 100 nM decreased it (−15...