IMPACT OF MALNUTRITION ON LONG-TERM SURVIVAL IN ADULT PATIENTS AFTER ELECTIVE CARDIAC SURGERY

Abstract Introduction The aim of this study was to investigate the relationship between malnutrition and long-term survival in patients that underwent cardiopulmonary bypass (CPB). Materials and Methods : This study analyzed the long-term survival data of mixed cohort of 1187 cardiac patients previously enrolled in a prospective observational study of nutritional screening in cardiac surgery (NCT01366807). Nutritional status was assessed using the Malnutrition Universal Screening Tool (MUST). Results : Mean age of patients was 58.86 ±10.07 years [95% CI, 58.2-59.4]. The median time of follow-up was 73.4 months (25th to 75th percentiles, 18.3–101.3). In total, 449 (37.8%) patients were lost to follow-up after hospitalization, while for the remaining participants, the overall 8-year survival was 68% [95% confidence interval (CI), 59–76] and 77% [95% CI, 73–80] (log-rank, p=0.12) in patients with and without malnutrition risk, respectively. Statistically significant differences in survival were found during the 3-year follow-up of patients with HVD: 83% [95% CI, 74–92] with malnutrition vs. 93% [95% CI, 90–96] without malnutrition (log-rank, p=0.03). The final multivariate Cox regression model revealed logistic EuroSCORE (hazard ratio (HR) 1.337, 95% CI 1.110–1.612), CPB time Conclusion Preoperative malnutrition is not associated with 8-year mortality in mixed cardiac surgery cohort. However, it may be associated with a worse 3-year outcomes in patients with HVD.