Different effects of inhibitors on the O - and N -demethylation of codeine in human liver microsomes
1997
Objective: The O- and N-demethylation of codeine is catalysed by CYP2D6 and CYP3A4 respectively. The formation rates of morphine by O-demethylation and norcodeine by N-demethylation were studied in two sets of human liver microsomes.
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