Total synthesis of prostaglandin-E2 by rearrangement of a 6,8-disubstituted-2-oxabicyclo[3.2.1]octan-3-one to a 4,5 disubstituted-perhydrocyclopenta[b]furan-2-one.

1979

The bis-silyloxylactone (5) has been converted into a prostaglandin-E2 intermediate (7) using HCl or tetrabutylammonium fluoride.

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