A Rare Variant Translocation (t(5;9;22)(q13;q34;q11.2)) In A Case With Chronic Myeloid Leukemia

Chronic myeloid leukemia is a severe hematologic disorder with blastic transformation following  a chronic phase. The specific cytogenetic findings of the disorder is t (9; 22) or Philadelphia  (Ph1) chromosome. Ph1 is detected in most cases (95%). However, when a diffrent chromosome  other than 9 and 22 chromosomes are involved in translocation, the typical appearance of Ph1  chromosome does not occur and can be missed. In this case, the anomaly which is not detected  in conventional cytogenetic analysis can be determined by molecular cytogenetics (FISH)  analysis. In this paper we describe a unique clonal abnormality, t(5;9;22)(q13;q34;q11.2)- as a  rare variant translocation in a case with chronic myeloid leukemia.