[Increasing the effectiveness of skin cancer T(2-3) N0M0 radiotherapy by use of radiosencibilizers].

: The paper presents an attempt to increase the effectiveness of radiotherapy of locally advanced skin cancer by use of radiomodifiers. With this aim the researchers used metronidozol (MZ) and low-intensive laser emission (LILE), whoes radiosensibilizing activity is based on overcoming radioresistance of tumor hypoxic cell fraction. In order to increase MZ concentration in the tumor and eleminate its toxic effect the authors developed a new radiosensibilization technique, implying local use of a drug applicator. The technique is based on use of textile materials with specifed medical qualities (the method of their production was developed by the Scientific and Practical Association "Textileprogress"). The second direction of the research consisted in use of low-intensive laser emission as a radiosensibilizer, which was considered to be possible due to theoretical and experimental data suggesting the LILE capability of activating microcirculation in tumor and surrounding tissues. According to the authors of the article, the improvement of tumor microsirculation must increase tumor cell oxygenation, thus increasing their radiosensitivity. Applying radiosensibilization of hypoxic cells with MZ and LILE in radiotherapy of T2 basal cell and squamous cell carcinomas with the tumor size 4-5 cm and T3 tumors using original dose fractioning regimens (TFD 72 to 73 Gy) allows significant improvement of immediate treatment results without increase in local radioreactions and without substantial influence of the recurrence rate.