Survival of Patients With Spinal Muscular Atrophy Type 1

BACKGROUND: Spinal muscular atrophy type 1 (SMA1) is a progressive disease and is usually fatal in the first year of life. METHODS: A retrospective chart review was performed of SMA1 patients and their outcomes according to the following choices: letting nature take its course (NT); tracheostomy and invasive mechanical ventilation (TV); continuous noninvasive respiratory muscle aid (NRA), including noninvasive ventilation; and mechanically assisted cough. RESULTS: Of 194 consecutively referred patients enrolled in this study (103 males, 91 females), NT, TV, and NRA were chosen for 121 (62.3%), 42 (21.7%), and 31 (16%) patients, respectively. Survival at ages 24 and 48 months was higher in TV than NRA users: 95% (95% confidence interval: 81.8%–98.8%) and 67.7% (95% confidence interval: 46.7%–82%) at age 24 months ( P < .001) and 89.43% and 45% at age 48 months in the TV and NRA groups, respectively ( P < .001). The choice of TV decreased from 50% (1992–1998) to 12.7% (2005–2010) ( P < .005) with a nonstatistically significant increase for NT from 50% to 65%. The choice of NRA increased from 8.1% (1999–2004) to 22.7% (2005–2010) ( P < .001). CONCLUSIONS: Long-term survival outcome is determined by the choice of the treatment. NRA and TV can prolong survival, with NRA showing a lower survival probability at ages 24 and 48 months. * Abbreviations: CI — : confidence interval MAC — : mechanically assisted coughing NIV — : noninvasive bilevel ventilation NRA — : noninvasive respiratory aid NT — : no treatment SMA — : spinal muscular atrophy SMA1 — : spinal muscular atrophy type 1 Spo2 — : pulse oxygen saturation TV — : tracheostomy and invasive mechanical ventilation