Reconstruction and validation of iTR383, a genome-scale metabolic model for Helicobacter pylori 26695

Helicobacter pylori 26695, a highly pathogenic bacterium, is a human gastric epithelia colonizer, correlated with the development of duodenal and gastric ulcers, and gastric cancer worldwide. Its genome has been previously sequenced and annotated, and two genome-scale metabolic models have been developed; however, since their publication, vast amounts of data and new methodologies have been developed. In order to maintain accurate and relevant the information on this bacterium, and to generate new information and new approaches for its analysis, the assignment of new functions to H. pylori 26695’s genes was performed and a new genome-scale metabolic model was reconstructed.