Long-term surgical and patient-reported outcomes of Hirschsprung's Disease.

Abstract Background : Information is needed regarding the complex relationships between long-term functional outcomes and health-related quality of life (HRQoL) in Hirschsprung's Disease (HSCR). We describe long-term outcomes across multiple domains, completing a core outcome set through to adulthood. Methods : HSCR patients operated at a single centre over a 35-year period (1978-2013) were studied. Patients completed detailed questionnaires on bowel and urologic function, and HRQOL. Patients with learning disability (LD) were excluded. Outcomes were compared to normative data. Data are reported as median [IQR] or mean (SD). Results : 186 patients (median age 28 [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] years; 135 males) completed surveys. Bowel function was reduced (BFS 17 [14] , [15] , [16] , [17] , [18] , [19] vs. 19 [19] , [20] , p η 2=0•22). Prevalence and severity of fecal soiling and fecal awareness improved with age (p Conclusion : Functional impairment is common after pull-through, but bowel function improves with age. Clustering of poor functional outcomes across multiple domains identifies a need for early recognition and long-term support for these patients.